Back to results
US 7,745,571 B2Granted
Peptide inhibitors of IASPP
AssigneesLudwig Institute for Cancer Research, Genome Research Limited, Ucl Cruciform Limited
InventorsXin Lu, Patricia Kuwabara, David Selwood
Life of this patent
Estimating the term…
Abstract
The invention relates to a polypeptide or part thereof which inhibits the apoptotic activity of the tumor suppressor protein p53, and includes screening methods to identify agents which interfere with the activity of the polypeptide.
Claims16
An isolated peptide consisting of an amino acid sequence selected from the group consisting of:
- DGPEETD (SEQ ID NO:
- 2);
- GPEETD (SEQ ID NO:
- 1);
- TTLSDG (SEQ ID NO:
- 3);
- AEFGDE (SEQ ID NO:
- 8, amino acids 294-299);
- or PRNYFG (SEQ ID NO:
- 4).
7 more elements
An isolated peptide that is 6-20 amino acids in length and that comprises the sequence AEFGDE (SEQ ID NO:
- 8, positions 294-299), wherein the isolated peptide is capable of inhibiting iASPP binding to p53.
An isolated peptide consisting of:
- (a) an amino acid sequence selected from the group consisting of:
- DGPEETD (SEQ ID NO:
- 2);
- GPEETD (SEQ ID NO:
- 1);
- TTLSDG (SEQ ID NO:
- 3);
- AEFGDE (SEQ ID NO:
- 8, amino acids 294-299);
- or PRNYFG (SEQ ID NO:
- 4);
- and (b) an arginine tag.
9 more elements
An isolated peptide consisting of amino acids AEFGDE (SEQ ID NO:
- 8, amino acids 294-299) attached to an arginine tag.
Dependencies are inferred from the claim text.