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AssigneesBecton, Dickinson and Company, Research Foundation of the City University of NY
InventorsAndrew Auerbach, Bhanu P. S. Chauhan, Richard P. Clarke, M. Ishaq Haider, Umar Latif
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The present invention provides multi-arm siloxane-based molecules suitable for use as a drug delivery vehicle comprising a central core molecule that comprises a cyclic or cubic siloxane, and a plurality of arms attached to the central core molecule, wherein each arm comprises an organic moiety. The multi-arm siloxane-based molecules described herein are suitable for encapsulation of a therapeutic agent. The invention further includes pharmaceutical compositions comprising the claimed multi-arm siloxane-based molecules and an encapsulated therapeutic agent in combination with a pharmaceutically acceptable carrier. Methods of making and using the multi-arm siloxane-based molecules are also provided.
A multi-arm siloxane-based molecule for use as a drug delivery vehicle comprising a central core molecule that comprises a cyclic siloxane and a plurality of arms attached to the central core molecule, wherein each arm comprises an organic moiety, and wherein one or more of insulin, cisplatin, or paclitaxel is encapsulated in the molecule.
A pharmaceutical composition comprising:
A pharmaceutical composition comprising
Dependencies are inferred from the claim text.