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US 7,745,492 B2Granted
Carboxamido opioid compounds
AssigneeJanssen Pharmaceutical N.V.
InventorsJohn R. Carson, Philip M. Pitis
Life of this patent
Estimating the term…
Abstract
This invention is directed to carboxamido opioid compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
Claims4
A method for treatment of pain in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of:
- 3-[(1-RS, 2-SR)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- 3-[(1-RS, 2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- (−)-3-[(1R, 2R)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- (+)-3-[(1S, 2S)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- 3-[(1-RS, 2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-N,N- diethylbenzamide;
- N-cyclopropyl-3-[(1-RS, 2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- and
- 3-[(1-RS, 2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-N-methylbenzamide.
5 more elements
A pharmaceutical composition comprising a compound selected from the group consisting of:
- 3-[(1-RS, 2-SR)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- 3-[(1-RS, 2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- (−)-3-[(1R, 2R)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- (+)-3-[(1S, 2S)-rel-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- 3-[(1-RS, 2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-N,N- diethylbenzamide;
- N-cyclopropyl-3-[(1-RS, 2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-benzamide;
- and
- 3-[(1-RS, 2-RS)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]-N-methylbenzamide.
5 more elements
Dependencies are inferred from the claim text.