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US 7,745,491 B2Granted
Substituted phenylacetamides and their use as glucokinase activators
AssigneeProsidion Limited
InventorsMatthew Colin Thor Fyfe, Vilasben Kanji Shah
Life of this patent
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Abstract
Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Claims18
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- V is (CH2)k;
- where one CH2 group is replaced by CH(OH) or C═O;
- R1 is SO2R4;
- T together with the —N═C— represents pyrazolyl, pyrazinyl or pyridazinyl;
- R2 and R3 each independently are hydrogen, halogen, OCFnH3-n, methoxy, CO2R5, cyano, nitro, CHO, CONR6R7, CON(OCH3)CH3, or C1-2alkyl;
- R4 is a C3-7cycloalkyl group;
- R5 is hydrogen, or a C1-4alkyl group;
- R6 and R7 each independently are hydrogen or a C1-4alkyl group;
- n is 1, 2 or 3;
- k is 4 or 5;
- m is 0 or 1;
- and
- the dotted line together with the solid line forms an optional double bond, and Δ indicates that the double bond has the (E)-configuration.
11 more elements
Dependencies are inferred from the claim text.