Heteroaryl and benzyl amide compounds
AssigneeHoffman-La Roche Inc.
InventorsAurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
Life of this patent
Estimating the term…
Abstract
Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.
Claims17
A compound of formula I:
- or pharmaceutically acceptable salts thereof, wherein:
- R1 is C1-C6alkyl, halo-C1-C6alkyl, halo-C1-C6alkoxy, C3-C8cycloalkyl, halo-C3-C8cycloalkyl or tri-C1-C6alkylsilyl;
- R2 is a group:
- wherein:
- R6 and R7 are independently hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- R8 and R9 are independently hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- X is CR12;
- Y is CH;
- R12 is halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- R5 is halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- R4 is hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- A is CR10 or N;
- wherein R10 is hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- B is CR11 or N;
- wherein R11 is hydrogen;
- or R11 is C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy, when at least two of R3, R4, R5 and R10 are not hydrogen;
- D is CR3 or N;
- wherein R3 is hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- wherein -B=A- and -A=D- are not —N═N—;
- and at least two of R3, R4, R5, R10 and R11 are not hydrogen;
- and
- n is 1, 2 or 3.
N-(4-tert-Butyl-benzyl)-3-chloro-N-[2-(4-chloro-3-ethyl-phenyl)-ethyl]-2-fluoro-5-trifluoromethyl-benzamide or a pharmaceutically acceptable salt thereof.
N-(4-tert-Butyl-benzyl)-3-chloro-N-[2-(4-chloro-3-ethyl-phenyl)-ethyl]-2-fluoro-5-trifluoromethyl-benzamide.
Dependencies are inferred from the claim text.