Compound
AssigneeSterix Limited
InventorsBarry Victor Lloyd Potter, Lok Wai Lawrence Woo, Atul Purohit, Michael John Reed, Oliver Brook Sutcliffe, Christian Bubert
Life of this patent
Estimating the term…
Abstract
There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
Claims27
A method of treatment for use in the therapy of breast cancer, prostate cancer, ovarian cancer or endometrial cancer comprising administration of a pharmaceutical composition comprising a compound of Formula IIId
- wherein
- i)
- E is an optional linker group;
- R is a 5-, 6- or 7-membered carbocyclic ring;
- P is an optionally substituted 5- or 6-membered heterocyclic ring containing 1 to 3 hetero atoms selected from the group consisting of N, O and S;
- Q is a polycyclic ring system:
- at least Q comprises a sulphamate group;
- and
- at least one of P, Q and R is optionally substituted by one or more halo atoms or
- ii)
- E is an optional linker group;
- R is a 5-, 6- or 7-membered carbocyclic
- P is an optionally substituted 5- or 6-membered heterocyclic ring containing 1 to 3 hetero atoms selected from the group consisting of N, O and S;
- Q is a 5-, 6- or 7-membered ring:
- at least Q comprises a sulphamate group;
- and
- at least one of P, Q and R is substituted by one or more halo atoms.
Dependencies are inferred from the claim text.