Compounds for treatment of cell proliferative diseases
AssigneeBoard of Regents, The University of Texas Systems
InventorsWaldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki
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Abstract
The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
Claims23
A compound comprising the chemical formula:
- wherein R0 is chosen from the group consisting of:
- where X1, X2, X3, and X4, are each independently selected from the group consisting of hydrogen, halogen, OH, and NO2;
- R2 is selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, alkylaryl, halogen, hydrogen, OH, NO2, thioether, amine, SH, and NH2;
- R3 is
- where R4 is CN;
- where Z is NH, and
- where X5 and X6 are each independently chosen from the group consisting of hydrogen and lower alkyl.
A method of treating atherosclerosis, pulmonary fibrosis, myelofibrosis, chronic myeloid, leukemia, myeloma tumors, squamous cell carcinoma, keratinocyte proliferation or psoriasis, comprising administering a therapeutically relevant amount of a first compound to a subject;
- wherein the amount of the first compound is effective to treat atherosclerosis, pulmonary fibrosis, myelofibrosis, chronic myeloid, leukemia, myeloma tumors, squamous cell carcinoma, keratinocyte proliferation or psoriasis;
- and wherein the first compound has the chemical formula:
- wherein R0 is chosen from the group consisting of:
- where X1, X2, X3, and X4, are each independently selected from the group consisting of hydrogen, halogen, OH, and NO2;
- R2 is selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, alkylaryl, halogen, hydrogen, OH, NO2, thioether, amine, SH, and NH2;
- R3 is
- where R4 is CN;
- where Z is NH, and
- where X5 and X6 are each independently chosen from the group consisting of hydrogen and lower alkyl.
Dependencies are inferred from the claim text.