Method of treating dry eye disorders

A method for the treatment of dry eye in a mammal, which comprises topically administering to the eye of the mammal a composition comprising a pharmaceutically acceptable carrier and 0.1-1% (w/v) of an inhibitor of the EgLN-3 enzyme, wherein the EgLN-3 inhibitor is selected from the group consisting of:

• wherein:
• R is H, C1-6 straight chain or branched alkyl, phenyl, or benzyl, or CO2R forms a salt of formula CO2−M+, with M+ being Li+, Na+, K+, or NH4+;
• and
• R1 is H, C(O)CH3, or C(O)C6H5.