Pyrazolo[1,5-c]pyrimidines

A compound of formula I

• in which
• R1 is Ar1, or
• Har1, Har2 or Har3, or
• Cyc1, or
• Hh1, Ah1 or Ha1, in which
• Ar1 is optionally substituted by R11, and is phenyl, naphthyl, fluorenyl or Aa1, in which
• Aa1 is a bisaryl radical made up of two aryl groups, which are independently selected from the group consisting of phenyl and naphthyl, and which are linked together via a single bond,
• R11 is 1-4C-alkoxy, 1-4C-alkoxy-2-4C-alkoxy, halogen, nitro, hydroxyl, phenoxy, phenyl-1-4C-alkoxy, hydroxy-2-4C-alkoxy, carboxy-1-4C-alkoxy or 1-4C-alkylcarbonylamino,
• Har1 is optionally substituted by R12, and is an unsaturated monocyclic 5- or 6-membered heteroaryl radical comprising one to four heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulphur, in which
• R12 is 1-4C-alkyl,
• Har2 is optionally substituted by R13, and is an unsaturated fused bicyclic 9- or 10-membered heteroaryl radical comprising one to four heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulphur, in which
• R13 is 1-4C-alkyl,
• Har3 is optionally substituted by R14, and is an unsaturated fused tricyclic 13- or 14-membered heteroaryl radical comprising one to four heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulphur, in which
• R14 is 1-4C-alkyl,
• Cyc1 is a group of formula A
• in which
• G is a 5- or 6-membered saturated or partially unsaturated heterocyclic ring comprising one or two heteroatoms independently selected from the group consisting of oxygen and sulfur,
• whereby said Cyc1 ring system is attached to the parent molecular group via any substitutable carbon atom,
• Hh1 is optionally substituted by R15, and is a bisheteroaryl radical made up of two heteroaryl groups, which are independently selected from the group consisting of monocyclic 5- and 6-membered heteroaryl radicals comprising one or two heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulfur, and which are linked together via a single bond, in which
• R15 is 1-4C-alkyl,
• Ah1 is optionally substituted by R16, and is an arylheteroaryl radical made up of an aryl group selected from the group consisting of phenyl and naphthyl, and a heteroaryl group selected from the group consisting of monocyclic 5- and 6-membered heteroaryl radicals comprising one or two heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulfur, whereby said aryl and heteroaryl groups are linked together via a single bond, in which
• R16 is 1-4C-alkyl,
• Ha1 is optionally substituted by R17, and is a heteroarylaryl radical made up of a heteroaryl group selected from the group consisting of monocyclic 5- and 6-membered heteroaryl radicals comprising one or two heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulfur, and an aryl group selected from the group consisting of phenyl and naphthyl, whereby said heteroaryl and aryl groups are linked together via a single bond, in which
• R17 is 1-4C-alkyl,
• whereby each of the radicals Har1, Har2, Har3, Hh1 and Ah1 is bonded via a ring carbon atom to the pyrazolopyrimidine scaffold;
• R2 is hydrogen, halogen or 1-4C-alkyl;
• R3 is -T-R30, —U—Ar2, —V—Har4, or Cyc2, in which
• T is 1-4C-alkylene,
• R30 is —N(R301)R302, cyano, amidino, carbamoyl, guanidino, ureido, 1-4C-alkylsulfonyl, or Het2, in which
• R301 is hydrogen, 1-4C-alkyl, 1-4C-alkoxycarbonyl, hydroxy-2-4C-alkyl or 1-4C-alkoxy-2-4C-alkyl,
• R302 is hydrogen or 1-4C-alkyl,
• or R301 and R302 together and with inclusion of the nitrogen atom to which they are bonded form a radical Het1, in which
• Het1 is a monocylic 3- to 7-membered saturated heterocyclic ring comprising the nitrogen atom, to which R301 and R302 are attached, and optionally one further heteroatom selected from the group consisting of oxygen, nitrogen, N(R303) and sulfur, in which
• R303 is hydrogen, 1-4C-alkyl or 1-4C-alkoxycarbonyl,
• Het2 is a monocylic 3- to 7-membered saturated heterocyclic ring,
• which comprises one nitrogen atom and optionally one further heteroatom selected from the group consisting of oxygen, nitrogen, N(R304) and sulfur, whereby said Het2 radical is attached to the parent molecular group via a ring carbon atom, in which
• R304 is 1-4C-alkyl,
• U is a bond, 1-4C-alkylene, or 1-4C-alkylene substituted with amino-1-4C-alkyl,
• Ar2 is phenyl, or R31- and /or R32-substituted phenyl, in which
• R31 is 1-4C-alkyl, 1-4C-alkoxy, halogen, trifluoromethyl, or —W—R311, in which
• W is a bond or 1-4C-alkylene,
• R311 has one of the meanings of R30 as defined above,
• R32 is halogen,
• V is a bond,
• Har4 is optionally substituted by R33, and is a monocyclic
• or fused bicyclic 5- to 10-membered unsaturated heteroaryl radical comprising one to four heteroatoms, each of which is selected from the group consisting of nitrogen, oxygen and sulfur, whereby said Har4 radical is attached to the moiety V via a ring carbon atom, in which
• R33 is -Z-R331, in which
• Z is 1-4C-alkylene,
• R331 has one of the meanings of —N(R301)R302 as defined above,
• Cyc2 is a group of formula A
• in which
• G is a 5- or 6-membered saturated heterocyclic ring comprising one nitrogen atom and optionally one further heteroatom selected from the group consisting of oxygen, nitrogen and sulfur,
• whereby said Cyc2 ring system is attached to the parent molecular group via any substitutable carbon atom;
• R4 is hydrogen or halogen;
• or a salt thereof.