Crystal forms of olanzapine and processes for their preparation
AssigneeKRKA, d.d. Novo mesto
InventorsBerta Kotar Jordan, Franc Vrecer, Marija Grcman
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Abstract
The invention relates to a process for the preparation of form I of olanzapine, crystallized from a solvent mixture which comprises 2-propanol, some pseudopolymorphic forms, namely solvates of olanzapine, a new polymorphic form A of olanzapine, and processes for the preparation thereof.
Claims23
Acetonitrile/methylene chloride/water mixed solvate of olanzapine characterized by an x-ray powder diffraction pattern (2 theta) as follows:
- 8.76, 19.39, 20.12.
Acetonitrile/water mixed solvate of olanzapine characterized by an x-ray powder diffraction pattern (2 theta) as follows:
- 8.76, 9.10, 14.05, 19.37, 20.10, 24.55, 25.92, 27.96.
2-propanol solvate of olanzapine characterized by an x-ray powder diffraction pattern as follows:
- 8.74, 14.05, 19.38, 22.65, 23.03, 24.46, 25.92, 28.36.
Methylene chloride solvate IA of olanzapine characterized by an x-ray powder diffraction pattern as follows:
- 10.80, 14.25, 19.22, 22.78, 24.53.
Methylene chloride solvate IB of olanzapine characterized by an x-ray powder diffraction pattern as follows:
- 9.30, 10.80, 14.25, 14.98, 15.94, 19.23, 20.04.
Form A of olanzapine characterized by an x-ray powder diffraction pattern as follows:
- 11.52, 12.00, 13.35, 13.56, 14.21, 15.47, 16.69, 19.16, 20.25 20.69, 22.12, 24.33, 26.88, 27.13.
Dependencies are inferred from the claim text.