Imidazo[1,2-A]pyridine having anti-cell-proliferation activity

A compound of formula (I):

• wherein:
• R1 is selected from halo, amino, C1-3alkyl, C1-3alkoxy, N—(C1-3alkyl)amino, N,N—(C1-3alkyl)2amino and a nitrogen linked 4-7 membered saturated ring which optionally contains an additional nitrogen, oxygen or sulphur atom;
• m is 0-4;
• wherein the values of R1 may be the same or different;
• R2 is selected from hydrogen, halo, amino, C1-3alkyl and C1-3alkoxy;
• R3 is hydrogen or halo;
• R4 is hydrogen, ethynyl, halo, cyano, hydroxy, amino, mesyl, trifluoromethyl, trifluoromethoxy, methyl, ethyl or methoxy;
• Ring A is a nitrogen linked 4-7 membered saturated ring which optionally contains an additional nitrogen, oxygen or sulphur atom;
• wherein if said ring contains an additional nitrogen atom that nitrogen may be optionally substituted by R6;
• R5 is a substituent on carbon and is selected from halo, cyano, hydroxy, trifluoromethoxy, amino, carboxy, carbamoyl, sulphamoyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkanoyl, N—(C1-6alkyl)carbamoyl, N,N—(C1-6alkyl)2carbamoyl, C1-6alkylS(O)a wherein a is 0 to 2, C1-6alkoxycarbonyl, N—(C1-6alkyl)sulphamoyl and N,N—(C1-6alkyl)2sulphamoyl;
• wherein R5 independently may be optionally substituted on carbon by one or more R7;
• or R5 is —NHR8, —NR9R10 or —O—R11;
• n is 0-4;
• wherein the values of R5 may be the same or different;
• R6 is selected from C1-6alkyl, C1-6alkanoyl, C1-6alkylsulphonyl, C1-6alkoxycarbonyl, carbamoyl, N—(C1-6alkyl)carbamoyl and N,N—(C1-6alkyl)carbamoyl;
• wherein R6 may be optionally substituted on carbon by one or more R12;
• R8, R9, R10 R11 are independently selected from C1-4alkyl, C1-4alkanoyl, C1-4alkylsulphonyl, C2-4alkenylsulphonyl, C2-4alkynylsulphonyl, C1-4alkoxycarbonyl, carbamoyl, N—(C1-4alkyl)carbamoyl, N,N—(C1-4alkyl)carbamoyl, carbocyclyl and heterocyclyl;
• wherein R8, R9, R10 and R11 may be independently optionally substituted on carbon by a group selected from R13;
• and wherein if said heterocyclyl contains an —NH— moiety that nitrogen may be optionally substituted by R14;
• R13 is selected from halo, cyano, hydroxy, amino, trifluoromethyl, trifluoromethoxy, C1-3alkyl and C1-3alkoxy;
• R14 is selected from C1-3alkyl, C1-3alkanoyl, C1-3alkylsulphonyl, C1-3alkoxycarbonyl, carbamoyl, N—(C1-3alkyl)carbamoyl and N,N—(C1-3alkyl)carbamoyl;
• and
• R7 and R12 are independently selected from halo, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, carboxy, carbamoyl, sulphamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulphinyl, ethylsulphinyl, mesyl, ethylsulphonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulphamoyl, N-ethylsulphamoyl, N,N-dimethylsulphamoyl, N,N-diethylsulphamoyl and N-methyl-N-ethylsulphamoyl;
• or a pharmaceutically acceptable salt thereof.