Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture

A glucopyranosyl-substituted benzonitrile derivative selected from the list according to formula II, III, or i.2,

• wherein
• R3 is cyclopentyloxy, cyclobutyloxy, cyclohexyloxy, tetrahydropyran-4-yloxy, 1-acetyl-piperidin-4-yloxy or C1-3-alkyloxy, and
• R′ denotes H, C1-4-alkyl, (C1-18-alkyl)carbonyl, (C1-18-alkyl)oxycarbonyl, arylcarbonyl or aryl-(C1-3-alkyl)-carbonyl, wherein the alkyl or aryl groups may be mono- or polysubstituted by halogen;
• R8a, R8b, R8c, R8d independently of one another denote hydrogen or an allyl group, a benzyl group, a (C1-4-alkyl)carbonyl, (C1-4-alkyl)oxycarbonyl, arylcarbonyl, aryl-(C1-3-alkyl)-carbonyl and aryl-(C1-3-alkyl)-oxycarbonyl or a RaRbRcSi group or a ketal or acetal group, particularly an alkylidene or arylalkylidene ketal or acetal group, while in each case two adjacent groups R8a, R8b, R8c, R8d may form a cyclic ketal or acetal group or a 1,2-di(C1-3-alkoxy)-1,2-di(C1-3-alkyl)-ethylene bridge, while the above-mentioned ethylene bridge forms, together with two oxygen atoms and the two associated carbon atoms of the pyranose ring, a substituted dioxane ring, particularly a 2,3-dimethyl-2,3-di(C1-3-alkoxy)- 1,4-dioxane ring, and while alkyl, allyl, aryl and/or benzyl groups may be mono- or polysubstituted by halogen or C1-3-alkoxy, and while benzyl groups may also be substituted by a di-(C1-3-alkyl)amino group;
• and
• Ra, Rb, Rc independently of one another denote C1-4-alkyl, aryl or aryl-C1-3-alkyl, wherein the aryl or alkyl groups may be mono- or polysubstituted by halogen;
• while by the aryl groups mentioned in the definition of the above groups are meant phenyl or naphthyl groups;
• and
• Alk denotes C1-4-alkyl.