Bladder tumor-targeting peptide and use thereof
AssigneesKyungpook National University Industry-Academica Cooperation Foundation, Burnham Institute for Medical Research
InventorsErkki Ruoslahti, Byung-Heon Lee, In-San Kim
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Abstract
The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according to the present invention is capable of specific binding to bladder tumor cells in vivo and in vitro. The peptide according to the present invention or an antibody thereof is useful for a marker for the diagnosis of bladder tumors, and for a drug carrier targeting bladder tumor.
Claims8
An isolated peptide that targets bladder tumor cells, which comprises an amino acid sequence represented by the formula:
- Cys Xaa Asn Xaa Asp Xaa Arg Xaa Cys (SEQ ID NO:
- 7);
- wherein,
- the second amino acid (Xaa) is selected from the group consisting of serine (S), proline (P), alanine (A) and valine (V);
- the fourth amino acid (Xaa) is selected from the group consisting of arginine (R), glycine (G), lysine (K), glutamine (Q), asparagine (N) and leucine (L);
- the sixth amino acid (Xaa) is selected from the group consisting of alanine (A), glutamic acid (E), valine (V), serine (S), glutamine (Q) and threonine (T);
- and
- the eighth amino acid (Xaa) is selected from the group consisting of arginine (R), asparagine (N) and leucine (L).
Dependencies are inferred from the claim text.