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US 7,745,401 B2Granted
Antifungal peptides and methods of use thereof
AssigneeThe Board of Regents of the University of Oklahoma
InventorsH. Anne Pereira, Paul Fidel
Life of this patent
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Abstract
A method of treating fungal infections by treatment with CAP37 peptides and derivatives thereof, including peptide analogs having serine or threonine substitutions at least one of the two cysteine residues therein. Other substitutions of the amino acid residues of the peptide are also contemplated.
Claims20
A method of treating a fungal infection in a subject in need of such treatment, comprising:
- administering to the subject in need of treatment of the fungal infection a therapeutically effective amount of a peptide having 20-25 amino acids, the peptide comprising SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:12, SEQ ID NO:13, or SEQ ID NO:14, and wherein the peptide comprises an arginine residue immediately adjacent to a histidine residue.
A method of treating a fungal infection in a subject in need of such treatment, comprising:
- administering to the subject in need of treatment of the fungal infection a therapeutically effective amount of a peptide comprising 20 to 25 amino acids, the peptide comprising the sequence (SEQ ID NO:
- 15):
- R-H-X3-X4-X5-X6-X7-X8-X9-H-X11-R-X13-X14-M-X16-X17-X18-X19-X20
- wherein:
- X3 is phe, tyr, arg, lys or his;
- X4 is cys, ser, thr, arg, lys or his;
- X5 is gly, ala, arg, lys or his;
- X6 is gly, ala, arg, lys or his;
- X8, X9, X17, and X18 are selected from the group consisting of ala, leu, ile and val;
- X7, X11 and X14 are selected from the group consisting of ala, leu, ile, val, arg, lys, and his;
- X13 is phe or tyr;
- X16 is ser or thr;
- X19 is ser, thr, his, arg or lys;
- X20 is ser, cys or thr;
- R is arg;
- H is his;
- and
- M is met.
15 more elements
Dependencies are inferred from the claim text.