Use of SERP-1 as an antiplatelet agent
AssigneeViron Therapeutics, Inc.
InventorAlexandra Lucas
Life of this patent
Estimating the term…
Abstract
Compositions and methods for antiplatelet/anti-thrombotic therapy in a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1 admixed with a pharmaceutically acceptable carrier to a subject in need of such therapy. Methods of administering SERP-1 with at least one other antiplatelet agent are also provided. The compositions and methods of the present invention are useful for treating and preventing recurrence of numerous cardiovascular diseases and injuries.
Claims76
A method of treating a cardiovascular disease-related thrombosis or embolism in a mammalian subject undergoing stent placement, said method comprising administering a therapeutically effective amount of serine proteinase inhibitor-1 (SERP-1), SERP-1 analog, or biologically active fragment thereof and a pharmaceutically acceptable carrier to said subject, wherein said SERP-1, SERP-1 analog, or biologically active fragment thereof inhibits thrombolytic proteases urokinase-type plasminogen activator, tissue-type plasminogen activator, and plasmin in vitro.
A method of treating a cardiovascular abnormal condition-related thrombosis or embolism in a mammalian subject undergoing stent placement, said method comprising administering a therapeutically effective amount of serine proteinase inhibitor-1 (SERP-1), SERP-1 analog, or biologically active fragment thereof and a pharmaceutically acceptable carrier to said subject, wherein said SERP-1, SERP-1 analog, or biologically active fragment thereof inhibits thrombolytic proteases urokinase-type plasminogen activator, tissue-type plasminogen activator, and plasmin in vitro.
A method of treating a cardiovascular disease-related thrombosis or embolism in a mammalian subject in need thereof, comprising administering a therapeutically effective amount of serine proteinase inhibitor-1 (SERP-1), SERP-1 analog, or biologically active fragment thereof and at least one other antiplatelet agent and a pharmaceutically acceptable carrier to said subject, wherein said SERP-1, SERP-1 analog, or biologically active fragment thereof inhibits thrombolytic proteases urokinase-type plasminogen activator, tissue-type plasminogen activator, and plasmin in vitro.
A method of treating a cardiovascular abnormal condition-related thrombosis or embolism in a mammalian subject in need thereof, comprising administering a therapeutically effective amount of serine proteinase inhibitor-1 (SERP-1), SERP-1 analog, or biologically active fragment thereof and at least one other antiplatelet agent and a pharmaceutically acceptable carrier to said subject, wherein said SERP-1, SERP-1 analog, or biologically active fragment thereof inhibits thrombolytic proteases urokinase-type plasminogen activator, tissue-type plasminogen activator, and plasmin in vitro.
A method of reducing the occurrence of a cardiovascular disease-related thrombosis or embolism in a mammalian subject undergoing stent placement, said method comprising administering a therapeutically effective amount of serine proteinase inhibitor-1 (SERP-1), SERP-1 analog, or biologically active fragment thereof and a pharmaceutically acceptable carrier to said subject, wherein said SERP-1, SERP-1 analog, or biologically active fragment thereof inhibits thrombolytic proteases urokinase-type plasminogen activator, tissue-type plasminogen activator, and plasmin in vitro.
A method of reducing the occurrence of a cardiovascular abnormal condition-related thrombosis or embolism in a mammalian subject undergoing stent placement, said method comprising administering a therapeutically effective amount of serine proteinase inhibitor-1 (SERP-1), SERP-1 analog, or biologically active fragment thereof and a pharmaceutically acceptable carrier to said subject, wherein said SERP-1, SERP-1 analog, or biologically active fragment thereof inhibits thrombolytic proteases urokinase-type plasminogen activator, tissue-type plasminogen activator, and plasmin in vitro.
A method of reducing the occurrence of a cardiovascular disease-related thrombosis or embolism in a mammalian subject in need thereof, comprising administering a therapeutically effective amount of serine proteinase inhibitor-1 (SERP-1), SERP-1 analog, or biologically active fragment thereof and at least one other antiplatelet agent and a pharmaceutically acceptable carrier to said subject, wherein said SERP-1, SERP-1 analog, or biologically active fragment thereof inhibits thrombolytic proteases urokinase-type plasminogen activator, tissue-type plasminogen activator, and plasmin in vitro.
A method of reducing the occurrence of a cardiovascular abnormal condition-related thrombosis or embolism in a mammalian subject in need thereof, comprising administering a therapeutically effective amount of serine proteinase inhibitor-1 (SERP-1), SERP-1 analog, or biologically active fragment thereof and at least one other antiplatelet agent and a pharmaceutically acceptable carrier to said subject, wherein said SERP-1, SERP-1 analog, or biologically active fragment thereof inhibits thrombolytic proteases urokinase-type plasminogen activator, tissue-type plasminogen activator, and plasmin in vitro.
Dependencies are inferred from the claim text.