Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer
AssigneesUniversity of Victoria Innovatiion and Development Corporation, The Johns Hopkins University
InventorsSamuel R. Denmeade, John T. Isaacs, J. Thomas Buckley
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Abstract
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, the proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.
Claims30
A purified peptide comprising the amino acid sequence shown in SEQ. ID NO:4.
A method for treating prostate cancer in a subject, comprising contacting prostate cancer cells of the subject with a peptide consisting of the amino acid sequence shown in SEQ ID NO:4.
A method for treating prostate cancer in a subject, comprising administering a peptide consisting of the amino acid sequence shown in SEQ ID NO:4 to the subject.
Dependencies are inferred from the claim text.