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US 7,745,393 B2Granted
Minimalist bZIP proteins and uses thereof
OwnerJumi Shininventor
Life of this patent
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Abstract
The present invention provides minimalist bZIP proteins having a basic region derived from bHLH proteins fused to a leucine zipper dimerization domain derived from bZIP proteins and methods and uses thereof in the treatment of cancer. The present invention also provides pharmaceutical compositions for treating cancer.
Claims31
A minimalist bZIP protein consisting of:
- a) a basic region of a basic helix-loop-helix protein (bHLH);
- b) a hinge region;
- and
- c) a leucine zipper domain of a bZIP protein,
- wherein the minimalist bZIP protein binds a target DNA sequence.
2 more elements
A minimalist bZIP protein heterodimer comprising a first and second minimalist bZIP protein comprising a leucine zipper region in the first minimalist bZIP protein and a leucine zipper region in the second minimalist bZIP protein capable of forming a heterodimer;
- wherein the first minimalist bZIP protein and the second minimalist bZIP protein each consist of:
- a) a basic region of a basic helix-loop-helix protein (bHLH);
- b) a hinge region;
- and
- c) a leucine zipper domain of a bZIP protein.
2 more elements
Dependencies are inferred from the claim text.