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US 7,745,224 B2Granted
Procedure for the standardization of coagulation tests
AssigneeSiemens Healthcare Diagnostics Products GmbH
InventorsNorbert Zander, Matthias Wilkens
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Abstract
The present invention lies in the field of coagulation diagnosis and relates to a procedure for the standardization of coagulation tests, where calibrators are used to which a discrete standard coagulation time is assigned. The procedure is particularly suitable for the standardization of prothrombin time, activated partial thromboplastin time, thrombin time, ecarin time or batroxobin time.
Claims11
A method for the determination of a standardized coagulation time of a sample, comprising
- a) measuring the coagulation time of a sample in a test system:
- b) measuring the coagulation times of at least two calibrators, for which discrete standard coagulation times have been predetermined, in the same test system as used in step a);
- c) forming a calibration curve that plots the predetermined standard coagulation times of the calibrators versus the coagulation times of the calibrators measured in step b);
- and
- d) converting the coagulation time of the sample measured in step a) to a standardized coagulation time using the calibration curve formed in step c).
2 more elements
Dependencies are inferred from the claim text.