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US 7,745,222 B2Granted
Amyloid binding assays
AssigneeGeneral Electric Company
InventorsKenneth Michael Fish, Cristina Tan Hehir, Michael Christopher Montalto, Eric Dustin Agdeppa
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Abstract
Provided herein are amyloid-binding assays that simulate in situ brain conditions by combining binders with various A-beta species on mammalian brain tissue. In general the amyloid-binding assays comprise the steps of (a) contacting a mammalian brain tissue sample with at least one A-beta species; (b) applying a putative binder to the brain tissue sample; and (c) determining whether the putative binder binds to the A-beta species.
Claims13
A method of identifying a putative binder to bind an A-beta-derived polypeptide having SEQ ID:
- 1 comprising the steps of:
- (a) contacting a mammalian brain tissue sample with at least one A-beta-derived polypeptide having SEQ ID:
- 1;
- (b) applying a putative binder to the brain tissue sample;
- and
- (c) determining whether the putative binder binds to the A-beta-derived polypeptide having SEQ ID:
- 1.
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Dependencies are inferred from the claim text.