Back to results
US 7,745,192 B2Granted
Prothrombin activating protein
AssigneeVenomics PTY Limited
InventorsPaul Pantaleone Masci, John De Jersey, Martin Lavin
Life of this patent
Estimating the term…
Abstract
The invention relates to snake venom protease polypeptides and nucleic acid sequences encoding same. This invention also relates to methods of making and using the snake venom proteases, e.g., to promote haemostasis and prevent blood loss such as during surgery or for treatment of wounds resulting from accidents and other types of injury or trauma.
Claims27
A composition comprising an isolated snake venom protease (SVP), wherein the SVP comprises one light chain and one heavy chain,
- wherein the light chain shares at least 95% sequence identity with the light chain sequence set forth by residues 41-179 of SEQ ID NO:
- 2 and the heavy chain shares at least 86% sequence identity with the heavy chain sequence set forth by residues 210-467 of SEQ ID NO:2, wherein the SVP comprises at least one amino acid sequence selected from the group consisting of SEQ ID NO:
- 19-21,
- wherein the SVP does not require calcium, factor Va, or phospholipid for activity, and the SVP is an active SVP capable of processing prothrombin to thrombin, and
- wherein the composition has less than 30% contaminating protein.
2 more elements
Dependencies are inferred from the claim text.