Histone deacetylase and methods of use thereof
AssigneeThe J. David Gladstone Institutes
InventorsEric M. Verdin, Wolfgang Fischle, Franck O. Dequiedt
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Abstract
The present invention provides nucleic acid molecules that encode histone deacetylase, as well as recombinant vectors and host cells that include the subject nucleic acid molecules. Also provided are histone deacetylase polypeptide compositions. The histone deacteylase nucleic acid molecules are useful in a variety of diagnostic and therapeutic applications, which are also provided.
Claims14
An in vitro method of identifying an agent that reduces enzymatic activity of histone deacetylase-7 (HDAC-7), the method comprising:
- a) contacting an enzymatically active HDAC-7 polypeptide with a test agent, wherein said HDAC-7 polypeptide has at least 95% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:02;
- and
- b) determining the effect, if any, of the test agent on enzymatic activity of the HDAC-7 polypeptide.
An in vitro method of identifying an agent that reduces enzymatic activity of histone deacetylase-7 (HDAC-7), the method comprising:
- a) contacting an enzymatically active HDAC-7 polypeptide with a test agent, wherein the HDAC-7 polypeptide lacks amino terminal amino acid residues 1-437 of SEQ ID NO:2, and comprises amino acids 438 to 912 of the amino acid sequence set forth in SEQ ID NO:2;
- and
- b) determining the effect, if any, of the test agent on enzymatic activity of the HDAC-7 polypeptide.
Dependencies are inferred from the claim text.