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US 7,745,162 B2Granted
Compositions and methods for measuring levels of bioactive human hepcidin
AssigneeIntrinsic Lifesciences LLC
InventorsXavier Lauth, Mark E. Westerman, Vaughn E. Ostland, Jason A. Stannard, Michael W. Pennington
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Abstract
The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal.
Claims5
An immunoassay tracer reagent consisting of:
- (i) a hepcidin peptide consisting of SEQ ID NO:28 oxidatively folded;
- (ii) a hydrophilic spacer consisting of two (2-(2-Amino-Ethoxy) Ethoxy) Acetic Acid (AEEAc) residues, wherein the peptide of (i) is covalently linked to the hydrophilic spacer at the amino terminus of the peptide;
- and
- (iii) biotin covalently linked to the hydrophilic spacer of (ii).
1 more element
Dependencies are inferred from the claim text.