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US 7,745,155 B2Granted
In-vivo monitoring of circulating apoptotic cells
AssigneeMassachusetts General Hospital
InventorsCharles P. Lin, Xunbin Wei, Dorothy Sipkins
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AssigneeMassachusetts General Hospital
InventorsCharles P. Lin, Xunbin Wei, Dorothy Sipkins
Estimating the term…
The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in-vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest. In some embodiments, the circulating cells comprise apoptotic cells whose detection can allow, e.g., non-invasive monitoring of the efficacy of a cancer treatment, such as an anti-tumor or an anti-angiogenic therapy.
A method for non-invasive detection of non-viable cells in a subject using in-vivo flow cytometry, comprising
A method for real-time quantification of non-viable circulating cells using in-vivo flow cytometry in a live subject, comprising:
Dependencies are inferred from the claim text.