Preventives/remedies for myeloma tumor and method of diagnosing the same
AssigneeKowa Company, Ltd.
InventorsYukihiko Saeki, Hideyuki Kobayashi, Yuichiro Tabunoki
Life of this patent
Estimating the term…
Abstract
The present invention provides a preventive or therapeutic drug for a myeloma tumor and osteoclastic bone loss associating therewith, the drug containing as an active ingredient an osteopontin-production regulator or inhibitor; a screening method for a preventive or therapeutic drug for a myeloma tumor, characterized by determining osteopontin production regulatory or inhibitory effect; as well as a diagnostic kit for a myeloma tumor, characterized by including a reagent for measuring blood osteopontin level, and a diagnostic method.
Claims10
A method for identifying a compound that reduces the severity of myeloma comprising:
- contacting cells which produce osteopontin with a test compound and determining the amount of osteopontin produced in the presence of said test compound compared to the amount of osteopontin produced by the cells in the absence of said test compound,
- selecting a test compound which reduces the amount of osteopontin produced by said cells, and
- contacting said test compound, which reduces the amount of osteopontin produced, with myeloma tumor cells, and
- selecting a test compound which reduces the severity of myeloma.
Dependencies are inferred from the claim text.