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US 7,745,152 B2Granted
Method for determining genotoxicity
AssigneeRoche Palo Alto LLC
InventorsJohn David Allard, Dee Aud, Guochun Liao, Gary Allen Peltz
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Abstract
Methods and reagents for determining the genotoxicity of a compound based on genomic responses to contact therewith are provided.
Claims3
A method for determining the genotoxicity of a test compound, said
- method comprising:
- (a) contacting a viable murine myoblast test cell with said test compound;
- (b) determining the change in expression level of a murine indicator gene selected from the group consisting of 4833427G06 Rik (RIKEN cDNA) (SEQ ID NO:5) and murine Dda3 (Differential display and activated by p53)
- wherein an increase in expression of at least 1.5-fold in said murine myoblast test cell, compared to a murine myoblast cell comprising 4833427G06 Rik (RIKEN cDNA) (SEQ ID NO:
- 5) or murine Dda3, that is not exposed to the test compound, indicates that said test compound exhibits genotoxicity.
2 more elements
Dependencies are inferred from the claim text.