Peptides of the AT1 receptor and their uses
AssigneeMax-Delbruck-Centrum fur Molekulare Medizin
InventorsGerd Wallukat, Volker Homuth, Friedrich Luft
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Abstract
Disclosed are peptides of the AT1 receptor and their use for eliminating specifically binding, cell-physiologically active, pathological antibodies in preeclampsia and malign hypertension. The peptides may, for example, be used for the diagnosis of preeclampsia. Peptides having the sequence AFHYESQ (SEQ ID NO: 1), AVHYQSN (SEQ ID NO: 2), SHFYQTR (SEQ ID NO: 3), GYYFDTN (SEQ ID NO: 4) or ENTNIT (SEQ ID NO: 5) are preferred.
Claims12
A method for binding auto-antibodies comprising:
- providing isolated peptides of an AT1 receptor consisting essentially of at least one of amino acid sequences SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3 or SEQ ID NO:
- 4, wherein said peptides bind auto-antibodies occurring in patients with preeclampsia,
- contacting said peptides in vitro with a blood sample from a patient suspected of having preeclampsia under conditions permitting binding of said auto-antibodies with said peptide, and
- binding said auto-antibodies in said blood sample via said peptides, wherein preeclampsia is diagnosed via said binding.
A method of binding auto-antibodies against the angiotensin AT1 receptor in a blood sample in vitro comprising contacting an isolated peptide of the AT1 receptor with a body fluid under conditions permitting binding of said auto-antibodies with said peptide, wherein the peptide consists essentially of the amino acid sequence of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:3, or SEQ ID NO:4.
A method of binding auto-antibodies against the angiotensin AT1 receptor in maternal blood in vitro comprising contacting an isolated peptide of the AT1 receptor with the maternal blood under conditions permitting binding of said auto-antibodies with said peptide, wherein the Peptide consists essentially of the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.