Method of diagnosing risk of myocardial infarction by detection of specific gene polymorphisms
AssigneeNagoya Industrial Science Research Institute
InventorsYoshiji Yamada, Mitsuhiro Yokota
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Abstract
It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained.
Claims6
A method for diagnosing the risk of myocardial infarction, comprising the following steps (i) to (iii):
- (i) analyzing two polymorphisms (1) and (2) in a nucleic acid sample:
- (1) polymorphism at the base number position −1171 of the stromelysin 1 gene;
- and
- (2) polymorphism at the base number position −668 of the plasminogen activator inhibitor-1 gene;
- (ii) determining, based on the information about said polymorphism which was obtained in the step (i), the genotype of the nucleic acid sample;
- and
- (iii) assessing, based on the genotype determined, a genetic risk of myocardial infarction.
Dependencies are inferred from the claim text.