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US 7,745,134 B2Granted
Predicting post-treatment survival in cancer patients with microRNAs
AssigneesNational Taiwan University, Taichung Veterans General Hospital, National Chung Hsing University
InventorsJian-Wei Chen, Sung-Liang Yu, Hsuan-Yu Chen, Gee-Chen Chang, Chih-Yi Chen, Pan-Chyr Yang
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Abstract
This invention provides a method for predicting the post-treatment survival prospect of a cancer patient based on the expression level(s) of microRNAs hsa-miR137, hsa-miR372, hsa-miR182*, hsa-miR221, and hsa-let-7a in that cancer patient.
Claims6
A method of predicting post-treatment survival of a lung cancer patient, comprising
- detecting expression levels of microRNAs hsa-miR137, hsa-miR372, hsa-miR182*, hsa-miR221, and hsa-let-7a in a lung cancer patient who has been subjected to treatment;
- calculating a risk score of the patient based on the expression levels of these microRNAs;
- and
- determining prospect of post-treatment survival based on the value of the risk score.
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