Determining a predisposition to cancer
AssigneePomeranian Academy of Medicine
InventorsCezary Cybulski, Jan Lubinski, Bohdan Gorski, Bartlomiej Gliniewicz, Andrzej Sikorski, Tomasz Huzarski, Tadeusz Debniak, Jacek Gronwald, Tomasz Byrski
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Abstract
The present invention relates to methods and kits for determining a predisposition for developing cancer, e.g., prostate and/or breast cancer, due to a germline mutation of a NBS1 gene. The present invention also relates to surveillance protocols for developing cancer, e.g., prostate and/or breast cancer, due to germline mutation of a NBS1 gene.
Claims12
A method for detecting a predisposition to breast cancer in a human subject, comprising detecting in a biological sample from the human subject germline alteration 657del5 in the sequence of a NBS1 gene, and associating the alteration with a predisposition to breast cancer in the human subject, thereby detecting the predisposition.
Dependencies are inferred from the claim text.