Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
AssigneeThomas Jefferson University
InventorsScott A. Waldman, Jason Park, Stephanie Schulz
Life of this patent
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Abstract
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed.
Claims29
An in vitro method of screening an individual for metastatic colorectal cancer cells or metastatic stomach cancer cells or metastatic esophageal cancer cells comprising the step of examining a sample of extraintestinal tissue and/or body fluids from an individual to determine whether CDX1 is being expressed by cells in said sample wherein expression of said CDX1 indicates a possibility of metastatic colorectal cancer cells or metastatic stomach cancer cells or metastatic esophageal cancer cells in said sample, wherein said CDX1 is encoded by SEQ ID NO:1.
An in vitro method of screening an individual for metastatic colorectal cancer or metastatic stomach cancer or metastatic esophageal cancer comprising the step of examining a sample of extraintestinal tissue and/or body fluids from an individual to determine whether CDX1 gene transcription or translation product is present in said sample wherein the presence of CDX1 gene transcription or translation product in said sample indicates that the individual may have metastatic colorectal cancer or metastatic stomach cancer or metastatic esophageal cancer, wherein said CDX1 is encoded by SEQ ID NO:1.
A method of diagnosing an individual who has metastatic esophageal cancer in an individual who has previously been diagnosed with having esophageal cancer consisting of examining a body fluid or lymph node sample to detect the presence of CDX1 transcript or translation product wherein the presence of CDX1 transcript or translation product in said sample indicates that the individual has metastatic esophageal cancer.
A method of diagnosing an individual who has metastatic colorectal cancer in an individual who has previously been diagnosed with having colorectal cancer consisting of examining a body fluid or extraintestinal sample to detect the presence of CDX1 transcript or translation product wherein the presence of CDX1 transcript or translation product in said sample indicates that the individual has metastatic colorectal cancer.
An in vitro method of screening an individual for metastatic colorectal cancer cells comprising the step of examining a sample of extraintestinal tissue and/or body fluids from an individual to determine whether CDX1 is being expressed by cells in said sample wherein expression of said CDX1 indicates a possibility of metastatic colorectal cancer cells in said sample, wherein said CDX1 is encoded by SEQ ID NO:
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Dependencies are inferred from the claim text.