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AssigneeThe Regents of the University of California
InventorsSylvia M. Evans, Ju Chen, Chenleng Cai, Alessandra Moretti, Kenneth R. Chien, Karl-Ludwig Laugwitz
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The present invention provides in vitro methods of expansion and propagation of undifferentiated progenitor cells and more specifically undifferentiated progenitor cells containing Islet1, a marker apparently unique to proliferating cardiac stem cells. Methods are described for isolation of stem cell populations as well as for provoking expansion and propagation of undifferentiated progenitor cells without differentiation, to provide cardiac repair or improve cardiac function, for example.
An in vitro method of culturing and expanding a cell population of undifferentiated mammalian cardiac progenitor cells substantially free of differentiated cells, comprising:
An in vitro method of culturing and expanding a cell population of undifferentiated mammalian cardiac progenitor cells substantially free of differentiated cells, comprising:
An in vitro method of culturing and expanding a cell population of undifferentiated mammalian cardiac adult stem cells substantially free of differentiated cells, comprising:
Dependencies are inferred from the claim text.