Methods and compositions for treatment of lesioned sites of body vessels
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsFlorian Niklas Ludwig, Stephen Pacetti, Paul Consigny
Life of this patent
Estimating the term…
Abstract
Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.
Claims13
A method for treating a lesioned site in a body vessel comprising:
- supplying a nitric oxide source comprising a nitric oxide in a gaseous state to a delivery cannula;
- and
- delivering through the delivery cannula to a treatment site within a lumen of a body vessel the nitric oxide source.
Dependencies are inferred from the claim text.