Venlafaxine formulations and methods of preparing the same
AssigneeActavis Group HF.
InventorGrant Heinicke
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Abstract
A method of forming a multi-particulate dosage form using rotary granulation is described in which polyethylene oxide is employed as s binder in a rotary granulation process. A multi-particulate oral dosage form comprises a plurality of pellets, the pellets comprising a core having disposed thereon a core composition layer. The core composition layer comprises venlafaxine and a binder, wherein the binder comprises a polyethylene oxide. In other embodiments, the binder comprises a 1:2:1 bis (butyl methacrylate-co-(2-dimethylaminoethyl)methacrylate-co-methyl methacrylate.
Claims17
A multi-particulate oral dosage form, comprising a plurality of pellets, the pellets comprising a core having disposed thereon a core composition layer, the core composition layer comprising an admixture of venlafaxine and a binder, wherein the binder comprises polyethylene oxide, wherein the polyethylene oxide has an average molecular weight of about 100,000 to about 6,000,000, and wherein a ratio of polyethylene oxide to venlafaxine is about 1:30 to about 1:5.
A multi-particulate oral dosage form, comprising a plurality of pellets, the pellets comprising an inert sphere core having disposed thereon a core composition layer, the core composition layer comprising an admixture of venlafaxine, a plasticizer, and a binder, wherein the binder comprises a 1:2:1 (butyl methacrylate-co-(2-dimethylaminoethyl)methacrylate-co-methyl methacrylate).
Dependencies are inferred from the claim text.