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US 7,744,919 B2Granted
Block copolymer micelle composition having an enhanced drug-loading capacity and sustained release
AssigneePostech Foundation
InventorsKilwon Cho, Jae Young Lee
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Abstract
A micelle drug composition having an enhanced drug-loading capacity and improved sustained-release characteristics comprising an amphiphilic block copolymer including at least one hydrophilic blocks and at least one hydrophobic blocks. The block copolymer comprises functional groups selected from the group consisting of carboxyl, amine, hydroxyl, amide, thiol and sulfonic acid groups, in the hydrophobic block chain of the copolymer, and the average number of the functional groups range from 1.1 to 30.
Claims6
A micelle composition for drug deliver system comprising an amphiphilic block copolymer represented by formula (1):
- wherein R1 is H, C1-4 alkyl or C1-4 acyl;
- R2 is H, C1-9 alkyl, aryl or C1-9 arylalkyl;
- x is a number ranging from 10 to 400;
- y is a number ranging from 10 to 300;
- z is a number ranging from 1.1 to 30;
- a ratio, z/y ranges from 0.015 to 2;
- and
- W is selected from the group consisting of carboxyl, amine, hydroxyl, amide, thiol and sulfonic acid groups.
5 more elements
Dependencies are inferred from the claim text.