Vascular implant device
AssigneeThe Regents of the University of California
InventorsSong Li, Rahul G. Thakar
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Abstract
Vascular smooth muscle cells (VSMCs) adhere to and orient along micropatterned grooves having a depth of 1 to 10 μm and a width of 1 to 20 μm that are imposed on the surface of a vascular implant device. The VSMCs maintain an elongated morphology and reduced proliferation resulting in a decrease in occurrence of intimal hyperplasia upon device implantation.
Claims18
A vascular graft comprising a surface with a micropattern of parallel grooves and plateau regions, wherein vascular smooth muscle cells (VSMCs) can adhere and orient along said grooves, wherein the grooves have a depth of 1 to 10 μm, and a width of 1 to 20 μm, and the micropattern reduces proliferation of the VSMCs,
- wherein the graft is fabricated from a polymeric material selected from the group consisting of poly-(D,L-lactide-co-glycolide) (PLGA), poly-(dimethylsiloxane) (PDMS), poly-(L-lactide-co-caprolactone-co-glycolide) (PLCG), polycaprolactone (PCL), polylactic acid (PLA), polystyrene, polyurethane, ePTFE, and polyethylene terephthalate.
Dependencies are inferred from the claim text.