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AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsThomas W Dubensky, Jr., John M Polo, Barbara A Belli, Silvia Perri, Timothy C Fong
Estimating the term…
Expression cassettes are provided comprising a promoter operably linked to a nucleic acid molecule which, when transcribed in vivo, forms double-stranded RNA that induces the production of interferon. Expression cassettes also are provided comprising a promoter operably linked to a ribozyme or antisense nucleic acid molecule which, when transcribed in vivo, forms a ribozyme or antisense RNA molecule that stimulates an immune response. In addition, expression cassettes are provided comprising a promoter operably linked to a ribozyme or antisense nucleic acid molecule which, when transcribed in vivo, stimulates apoptosis. Finally, gene delivery vectors are provided which contain such expression cassettes, host cells containing the gene delivery vectors, and methods of utilizing the expression cassettes, gene delivery vectors, and host cells.
A method of stimulating an immune response to a selected antigen within a desired host, comprising administering to the host a gene delivery vector comprising an expression cassette, wherein the expression cassette comprises:
Dependencies are inferred from the claim text.