Recombinant herpes simplex virus useful for treating neoplastic disease
AssigneesThe University of Chicago, The UAB Research Foundation
InventorsRichard J. Whitley, Bernard Roizman
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Abstract
Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.
Claims28
A recombinant herpes simplex virus that preferentially kills tumor cells and not healthy cells, that expresses only one γ134.5 gene copy and that comprises an expressible tumor-growth-inhibiting cytokine-encoding DNA.
A method for treating neoplastic disease, the method comprising administering to a target tumor, a recombinant herpes simplex virus capable of expressing only one γ134.5 gene copy and comprising an expressible tumor-growth-inhibiting cytokine-encoding DNA, wherein the expressed cytokine augments tumor cell killing.
A pharmaceutical composition comprising in a pharmaceutically acceptable carrier, diluent, or adjuvant, a recombinant herpes simplex virus expressing only one γ134.5 gene copy, said virus comprising an expressible tumor-growth-inhibiting cytokine-encoding DNA, wherein the expressed cytokine augments tumor cell killing.
Dependencies are inferred from the claim text.