Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
AssigneeThe Scripps Research Institute
InventorFrancis V. Chisari
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Abstract
Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV polymerase, and are particularly useful in treating or preventing HBV infection, including methods for stimulating the immune response of chronically infected individuals to respond to HBV antigens.
Claims22
An HBV immunogenic peptide of 50 amino acids or less in length, wherein said immunogenic peptide comprises HBpol 526-535 (Phe-Leu-Leu-Ala-Gln-Phe-Thr-Ser-Ala-Ile;
- SEQ ID NO:30), and wherein said immunogenic peptide binds to an appropriate HLA molecule to form a complex recognized by cytotoxic T cells wherein said cytotoxic T cells recognize a native HBV antigen.
An immunogenic composition comprising an HBV immunogenic peptide of 50 amino acids or less in length and a pharmaceutically acceptable carrier, wherein said immunogenic peptide comprises HBpol 526-535 (Phe-Leu-Leu-Ala-Gln-Phe-Thr-Ser-Ala-Ile;
- SEQ ID NO:30), and wherein said immunogenic peptide binds to an appropriate HLA molecule to form a complex recognized by cytotoxic T cells wherein said cytotoxic T cells recognize a native HBV antigen.
Dependencies are inferred from the claim text.