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US 7,744,882 B2Granted
Soluble ErbB3 methods of detection and antibodies
AssigneeTumor Biology Investment Group, Inc.
InventorsNita J. Maihle, Hakjoo Lee
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AssigneeTumor Biology Investment Group, Inc.
InventorsNita J. Maihle, Hakjoo Lee
Estimating the term…
Regulation of sErbB3 isoforms in methods of regulating heregulin activity or ErbB receptor activities is disclosed. Cancer therapeutics and methods of therapeutically treating cancer comprising sErbB3 are also disclosed. Detection of sErbB3 in biological samples for risk assessment and prevention, screening, diagnosis, prognosis, theragnosis, evaluation of responsiveness to treatment, and/or monitoring of disease progression, recurrence, or metastasis of a cancer is disclosed as well. In examples, sErbB3 nucleic acid sequences, polypeptides, molecular probes, and antibodies are useful agents for regulation, expression, detection, and cancer therapeutics related to sErbB3.
An isolated antibody that specifically recognizes an sErbB3 polypeptide, wherein the antibody binds a unique carboxy terminal region of the sErbB3 polypeptide comprising amino acid residues 539-562 of SEQ ID NO:
A pharmaceutical composition comprising an sErbB3 antibody and a pharmaceutically acceptable carrier, wherein said sErbB3 antibody binds a unique carboxy terminal region of the sErbB3 polypeptide comprising amino acid residues 539-562 of SEQ ID NO:
A kit comprising an sErbB3 antibody and at least one informational material, wherein said sErbB3 antibody binds a unique carboxy terminal region of the sErbB3 polypeptide comprising amino acid residues 539-562 of SEQ ID NO:
Dependencies are inferred from the claim text.