Methods and compositions for treatment, prevention, suppression, and/or delaying the onset of type 1 diabetes
AssigneeThe Curators of the University of Missouri
InventorsHabib Zaghouani, Randal Keith Gregg
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Abstract
The present invention relates generally to methods and compositions for treatment, prevention, suppression, and/or delaying the onset of type 1 diabetes. More specifically, the present invention relates to the administration of a fusion protein comprising at least one immunoglobulin having one or more diabetogenic epitopes inserted within the variable region, for suspending, preventing or delaying the onset of type 1 diabetes.
Claims5
A soluble immunoglobulin-polypeptide chimera comprising an immunoglobulin having a CDR3 region, wherein a diabetogenic epitope comprising a polypeptide having amino acid sequence of SEQ ID No:
- 4 is inserted within the CDR3 region.
Dependencies are inferred from the claim text.