Anti-sclerostin antibodies
AssigneeEli Lilly and Company
InventorsAndrew Ihor Korytko, David Matthew Marquis, Eric Michael Smith, Barbara Anne Swanson
Life of this patent
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Abstract
Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
Claims10
An antibody, or antigen-binding portion thereof, that specifically binds human sclerostin, and comprises a heavy chain variable region and a light chain variable region, wherein:
- i) the heavy chain variable region has the amino acid sequence of SEQ ID NO:
- 14 and the light chain variable region has the amino acid sequence of SEQ ID NO:
- 17;
- ii) the heavy chain variable region has the amino acid sequence of SEQ ID NO:
- 15 and the light chain variable region has the amino acid sequence of SEQ ID NO:
- 18.
An antibody that specifically binds human sclerostin, and comprises a heavy chain polypeptide and a light chain polypeptide wherein:
- i) the heavy chain polypeptide has the amino acid sequence of SEQ ID NO:
- 2 and the light chain polypeptide has the amino acid sequence of SEQ ID NO:
- 5;
- ii) the heavy chain polypeptide has the amino acid sequence of SEQ ID NO:
- 3 and the light chain polypeptide has the amino acid sequence of SEQ ID NO:
- 6.
An antibody that specifically binds human sclerostin, and comprises a heavy chain polypeptide with the amino acid sequence of SEQ ID NO:
- 3 and a light chain polypeptide with the amino acid sequence of SEQ ID NO:
- 6.
A method of treating osteoporosis in a human subject in need thereof, comprising administering to said human subject an effective amount of an antibody comprising a heavy chain polypeptide with SEQ ID NO:
- 3, and a light chain polypeptide with SEQ ID NO:
- 6.
A method of increasing at least one of bone mass, bone mineral density, bone mineral content, or bone strength in a human subject in need thereof, comprising administering to said human subject an effective amount of an antibody comprising two heavy chains and two light chains, wherein each heavy chain has the amino acid sequence of SEQ ID NO:
- 3 and each light chain has the amino acid sequence of SEQ ID NO:
- 6.
A pharmaceutical composition, comprising an antibody comprising two heavy chains and two light chains, wherein each heavy chain has the amino acid sequence of SEQ ID NO:3 and each light chain has the amino acid sequence of SEQ ID NO:6, and a pharmaceutically acceptable carrier, diluent, or excipient.
Dependencies are inferred from the claim text.