US 7,744,869 B2 · Methods of treatment using electromagnetic field stimulated mesenchymal stem cells

Abstract

Methods of modifying stem cells and compositions of modified stem cells, in particular mesenchymal stem cells, using electric or electromagnetic fields. In various embodiments, the present invention's methods are for the treatment of a human or other mammal subject in need thereof, comprising providing an in vitro culture comprising mesenchymal stem cells, administering an electric stimulation to the in vitro culture, and implanting the mesenchymal stem cells into the subject. Methods also include treatment of a human or other mammal subject, comprising implanting mesenchymal stem cells into the subject, and administering an electric stimulation to the mesenchymal stem cells in situ. Other embodiments include methods of administering electric stimulation in conjunction with growth factors to stem cells.

Claims6

Dependent claims

A method of treatment of a human or other mammalian subject having a bone defect in need of enhanced bone formation, comprising:

implanting mesenchymal stem cells into the subject at the site of said defect,
administering an amount of bone morphogenic protein-2 (BMP-2) at the site of said defect to induce differentiation of said mesenchymal stem cells into osteoblasts, and
administering an electric stimulation comprising a pulsed electromagnetic field to the mesenchymal stem cells in situ,
wherein said electric stimulation potentiates the differentiation of said mesenchymal stem cells induced by said amount of BMP-2, forming bone at the site of said defect, with the result being more efficacious than either administering electrical stimulation or BMP-2 independently of one another.

1 more element

Dependencies are inferred from the claim text.

Methods of treatment using electromagnetic field stimulated mesenchymal stem cells

Life of this patent

Methods of treatment using electromagnetic field stimulated mesenchymal stem cells

Life of this patent

Abstract

Claims6