IL1-β Binding antibodies and fragments thereof
AssigneeXoma Technology Ltd.
InventorsLinda Masat, Mary Haak-Frendscho, Arnold H. Horwitz, Gang Chen, Marina Roell
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Abstract
An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 8 and SEQ ID NO: 9, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.
Claims10
An isolated IL-1β binding antibody or IL-1β binding fragment thereof comprising a heavy chain variable region of SEQ ID NO:
- 8 and a light chain variable region of SEQ ID NO:
- 9.
An isolated IL-1β binding antibody or IL-1β binding fragment thereof, wherein the antibody or fragment binds to human IL-1β with a dissociation constant less than 1 pM, and the antibody or fragment competes with the binding of an antibody comprising a light chain variable region of SEQ ID NO:
- 9 and a heavy chain variable region of SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.