Reduced bioirritant composition
AssigneeMinu, L.L.C.
InventorGholam A. Peyman
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Abstract
A method for reducing irritancy of ascorbic acid administered to a biological surface for anti-angiogenic, anti-oxidant, anti-inflammatory and other effects. It has been discovered that pH neutralized ascorbic acid retains the efficacy of non-pH neutralized ascorbic acid in reducing neovascularization, providing an anti-oxidant effect, etc. but is less irritating and thus enhances patient comfort and compliance. It may be administered into or on the eye, on skin, into a body cavity, etc. either alone or with other agents.
Claims10
A method of reducing neovascularization comprising administering to an individual a composition comprising an effective concentration from about 250 μg/ml to about 100 mg/ml of ascorbic acid in a composition neutralized to a pH of about 7 under conditions sufficient to reduce neovascularization wherein the composition further comprises at least one of an anti-irritant sweetener, a non-steroidal anti-inflammatory drug (NSAID), or a steroid, and wherein if topically administered the composition further comprises an NSAID.
A method of reducing ocular neovascularization comprising administering to an individual a composition comprising an effective concentration of ascorbic acid from about 250 μg/ml to about 100 mg/ml ascorbic acid adjusted to a pH of about 7 in a biocompatible composition under conditions sufficient to reduce ocular neovascularization wherein the composition further comprises an anti-irritant sweetener, a non-steroidal anti-inflammatory drug (NSAID), or a steroid, and wherein a topically administered composition contains an NSAID.
Dependencies are inferred from the claim text.