Systems and methods of de-endothelialization
AssigneeBoston Scientific Scimed, Inc.
InventorsPaul S. Seifert, Elaine Lee, Michael P. Wallace, Stephen C. Porter
Life of this patent
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Abstract
Apparatus and methods for treating a wall of an aneurysm formed in a vessel includes introducing a tubular member into the body lumen until a distal end of the tubular member is located within the aneurysm. A fluid is delivered via a lumen of the tubular member into the aneurysm to at least partially de-endothelialize the wall of the aneurysm, thereby causing an endothelium of the wall to generate fibrous tissue to strengthen the wall of the aneurysm.
Claims34
A method for disrupting an endothelium of a wall of a treatment site adjacent a body lumen, comprising:
- introducing a tubular member into the body lumen until a distal end of the tubular member is located within the treatment site;
- sealing the treatment site from the body lumen;
- and
- damaging the endothelium of the wall of the treatment site by delivering a cell-disrupting cytotoxic agent comprising a hypotonic fluid via a lumen of the tubular member into the treatment site, such that the cell-disrupting hypotonic fluid contacts the wall of the treatment site,
- wherein the treatment site comprises an aneurysm, an arterio-venous malformation, or a fistula.
A method for disrupting an endothelium of a wall of a treatment site adjacent a body lumen, comprising:
- introducing a tubular member into the body lumen until a distal end of the tubular member is located adjacent the treatment site, the distal end carrying an annular shaped member;
- expanding the annular shaped member until an outer wall of the annular shaped member substantially seals the treatment site from the body lumen, the annular shaped member comprising a passage extending therethrough to allow continued fluid flow along the body lumen;
- and
- damaging the endothelium of the wall of the treatment site by delivering a cell-disrupting cytotoxic agent comprising a hypotonic fluid into the treatment site, such that the cell-disrupting hypotonic fluid contacts the wall of the treatment site,
- wherein the treatment site comprises an aneurysm, an arterio-venous malformation, or a fistula.
A method for treating a treatment site adjacent a body lumen, the method comprising:
- introducing a tubular member into the body lumen until a distal end of the tubular member is located within the treatment site;
- substantially sealing the treatment site from the body lumen;
- aspirating fluid from within the treatment site;
- damaging an endothelium of a wall of the treatment site by delivering a cell-disrupting cytotoxic agent comprising a hypotonic fluid via the tubular member into the treatment site to contact and at least partially de-endothelialize the endothelium of the wall of the treatment site;
- and
- aspirating the cell-disrupting hypotonic fluid from the treatment site,
- wherein the treatment site comprises an aneurysm, an arterio-venous malformation, or a fistula.
Dependencies are inferred from the claim text.