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US 7,744,560 B2Granted
Implantable drug delivery system responsive to intra-cardiac pressure
AssigneeMedtronic, Inc.
InventorChester Struble
Life of this patent
Estimating the term…
Abstract
The invention is directed to techniques for monitoring the condition of a patient, such as a patient having congestive heart failure, and appropriately modifying the patient's drug therapy as a function of a pressure in the patient's heart, such as the estimated pulmonary artery diastolic pressure. The drugs may be administered by an implanted drug delivery device. The drug selection, the drug dosage or both may be controlled as a function of the pressure and/or the activity level of the patient.
Claims37
An implantable medical device comprising:
- a pressure monitor that estimates a pulmonary artery diastolic pressure as a function of a pressure in a heart of a patient,
- a processor that selects a drug that corresponds to the estimated pulmonary artery diastolic pressure, and
- a pressure sensor that generates a pressure signal as a function of the pressure in the heart of the patient, wherein the pressure monitor comprises a differentiating circuit that generates a derivative signal that is representative of a first derivative of the pressure signal, and
- wherein the pressure monitor estimates the pulmonary artery diastolic pressure as a function of the derivative signal.
1 more element
An implantable medical device comprising:
- a pressure monitor that estimates a pulmonary artery diastolic pressure as a function of a pressure in a heart of a patient,
- a processor that selects a drug that corresponds to the estimated pulmonary artery diastolic pressure, and
- a pressure sensor that generates a pressure signal as a function of the pressure in the heart of the patient, wherein the pressure monitor comprises a differentiating circuit that generates a derivative signal that is representative of a second derivative of the pressure signal, and
- wherein the pressure monitor estimates the pulmonary artery diastolic pressure as a function of the derivative signal.
1 more element
A method comprising:
- estimating a pulmonary artery diastolic pressure as a function of a pressure in a heart of a patient;
- wherein estimating the pulmonary artery diastolic pressure as a function of the pressure comprises:
- identifying a point of maximum slope in a pressure signal, the pressure signal a function of the pressure in the heart of the patient;
- and
- identifying the pressure value at the point of maximum slope in the pressure signal;
- selecting a drug therapy as a function of the estimated pulmonary artery diastolic pressure;
- controlling a drug delivery device to deliver a drug to the patient as a function of the selected drug therapy,
- generating a first derivative of the pressure signal during a cardiac cycle;
- and
- sensing the point on the pressure signal that corresponds to a maximum of the first derivative of the pressure signal is maximized.
7 more elements
A method comprising:
- estimating a pulmonary artery diastolic pressure as a function of a pressure in a heart of a patient;
- selecting a drug therapy as a function of the estimated pulmonary artery diastolic pressure;
- controlling a drug delivery device to deliver a drug to the patient as a function of the selected drug therapy,
- wherein, estimating the pulmonary artery diastolic pressure as a function of the pressure comprises:
- identifying a point of maximum slope in a pressure signal, the pressure signal a function of the pressure in the heart of the patient;
- and
- identifying the pressure value at the point of maximum slope in the pressure signal by
- sensing an R-wave of a cardiac cycle;
- generating the second derivative of the pressure signal during the cardiac cycle;
- and
- sensing the point on the pressure signal at which the second derivative of the pressure signal becomes negative after the R-wave.
8 more elements
An implantable medical device comprising:
- means for estimate pulmonary artery diastolic pressure comprising a pressure monitor that includes a differentiating circuit;
- means for select a drug therapy as a function of the estimated pulmonary artery diastolic pressure, wherein the means to select a drug therapy comprises a means to select at least one of a first drug and a second drug as a function of the estimated pulmonary artery diastolic pressure;
- and
- means for deliver a drug as a function of the selected drug therapy.
1 more element
An implantable medical device comprising:
- a pressure monitor that estimates a pulmonary artery diastolic pressure as a function of a pressure in a heart of a patient,
- a processor that selects a drug that corresponds to the estimated pulmonary artery diastolic pressure,
- a pressure sensor that generates a pressure signal as a function of the pressure in the heart of the patient;
- and
- a differentiating circuit that generates a derivative signal that is representative of a first derivative of the pressure signal,
- wherein the pressure monitor estimates the pulmonary artery diastolic pressure as a function of the derivative signal.
3 more elements
An implantable medical device comprising:
- a pressure monitor that estimates a pulmonary artery diastolic pressure as a function of a pressure in a heart of a patient,
- a processor that selects a drug that corresponds to the estimated pulmonary artery diastolic pressure,
- a pressure sensor that generates a pressure signal as a function of the pressure in the heart of the patient, and
- a differentiating circuit that generates a derivative signal that is representative of a second derivative of the pressure signal,
- wherein the pressure monitor estimates the pulmonary artery diastolic pressure as a function of the derivative signal.
2 more elements
A method comprising:
- estimating a pulmonary artery diastolic pressure as a function of a pressure in a heart of a patient;
- selecting a drug therapy as a function of the estimated pulmonary artery diastolic pressure;
- and
- controlling a drug delivery device to deliver a drug to the patient as a function of the selected drug therapy,
- wherein estimating the pulmonary artery diastolic pressure as a function of the pressure comprises:
- identifying a point of maximum slope in a pressure signal, the pressure signal a function of the pressure in the heart of the patient;
- and
- identifying the pressure value at the point of maximum slope in the pressure signal by
- generating the first derivative of the pressure signal;
- and
- sensing the point on the pressure signal that corresponds to a maximum of the first derivative of the pressure signal during a cardiac cycle.
8 more elements
A method comprising:
- estimating a pulmonary artery diastolic pressure as a function of a pressure in a heart of a patient;
- selecting a drug therapy as a function of the estimated pulmonary artery diastolic pressure;
- and
- controlling a drug delivery device to deliver a drug to the patient as a function of the selected drug therapy,
- wherein, estimating the pulmonary artery diastolic pressure as a function of the pressure comprises:
- identifying a point of maximum slope in a pressure signal, the pressure signal a function of the pressure in the heart of the patient;
- and
- identifying the pressure value at the point of maximum slope in the pressure signal by
- sensing an R-wave of a cardiac cycle;
- generating the second derivative of the pressure signal;
- and
- sensing the point on the pressure signal at which the second derivative of the pressure signal during the cardiac cycle becomes negative after the occurrence of the R-wave.
9 more elements
An implantable medical device comprising:
- means for estimate pulmonary artery diastolic pressure through a pressure monitor that comprises a differentiating circuit which generates a derivative signal that is representative of a first derivative of the pressure signal;
- means for select a drug therapy as a function of the estimated pulmonary artery diastolic pressure, wherein the means to select a drug therapy comprises a means to select at least one of a first drug and a second drug as a function of the estimated pulmonary artery diastolic pressure;
- and
- means for deliver a drug as a function of the selected drug therapy.
1 more element
Dependencies are inferred from the claim text.