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US 7,744,526 B2Granted
Bioreactor for the manufacture of tissue engineered blood vessels
AssigneeCytograft Tissue Engineering, Inc.
InventorsTodd N. McAllister, Nicolas L'Heureux
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Abstract
The invention relates to bioreactors having an enclosed chamber, a sheet growth module, a rollable mandrel, and a clamp for holding the sheet to the mandrel for rolling for the manufacture of a tissue engineered blood vessel (TEBV). The TEBV is made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding.
Claims48
A system for preparing tissue engineered blood vessels comprising:
- at least one module that contains a cultured tissue sheet;
- a first mandrel onto which said tissue sheet is rolled;
- a motion control device into which said first mandrel is fitted;
- and
- a clamping device that secures a leading edge of said tissue sheet onto said first mandrel to facilitate rolling of the tissue sheet on to the first mandrel.
2 more elements
A system for preparing tissue engineered blood vessels comprising:
- at least one module that contains a cultured tissue sheet;
- a first mandrel onto which said tissue sheet is rolled;
- a motion control device into which said first mandrel is fitted;
- and
- a clamping device that secures a leading edge of said tissue sheet onto said first mandrel during rolling of the tissue sheet on to the first mandrel.
2 more elements
Dependencies are inferred from the claim text.