Methods and apparatus for intracranial ultrasound delivery

A method for delivering ultrasound energy to a patient's intracranial space, the method comprising:

• forming at least one hole in the patient's skull to access a target location;
• advancing at least one ultrasound device having a distal portion through the hole, wherein the distal portion contains at least one transducer to allow transmission of ultrasound, and the distal portion can be moved to various locations within the intracranial space without causing damage;
• transmitting ultrasound energy at frequencies between 20 Khz and 10 MHz from the ultrasound delivery device for therapeutic treatment;
• wherein the ultrasound energy is transmitted and directed from outside a blood vessel to a blood clot in the patient's brain at the target location that resides in an intracerebral space of the patient's brain, inside of the blood vessel, to disrupt the blood clot;
• further comprising placing an introducer device into the at least one hole, with the at least one ultrasound delivery device advanced through the introducer device.