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US 7,612,207 B2Granted
Method for preparing clopidogrel 1,5-naphthalenedisulfonate or hydrate thereof
AssigneeHanmi Pharm. Co., Ltd.
InventorsKwee Hyun Suh, Sang Min Yun, Eun Sook Kim, Gwan Sun Lee
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Abstract
The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.
Claims8
A method for preparing clopidogrel 1,5-naphthalenedisulfonate of formula (I) or a hydrate thereof, which comprises:
- reacting a clopidogrel-acid addition salt of formula (II)
- with disodium 1,5-naphthalenedisulfonate of formula (III) or its hydrate
- in water, or a mixture of water and an organic solvent, wherein HX is an acid capable of reacting with clopidogrel to form an acid addition salt excluding naphthalenedisulfonate.
Dependencies are inferred from the claim text.