Pyrazole compounds

A compound of formula (IC) or (ID) or a salt, or N-oxide thereof:

• wherein R is hydrogen, chloro, bromo, or a phenylethyl group which is optionally substituted in the phenyl ring, and
• R2 is independently hydrogen, methyl, ethyl, n- or iso-propyl, hydroxyethyl, or benzyl;
• Alk2 and Alk3 are optionally substituted C1-C3 alkyl,
• m, r and s are independently 0 or 1,
• Z is —O—, —S—, —(C═O)—, —SO2—, —C(═O)O—, —OC(═O)—, —NRA—, —C(═O)NRA—,
• —NRAC(═O)—, —SO2NRA—, or —NRASO2—wherein RA is hydrogen or C1-C6 alkyl, and
• Q is an optionally substituted phenyl, pyridyl, furyl, thienyl, oxadiazolyl, imidazolyl, or morpholinyl,
• wherein “optionally substituted” means substituted with up to four substituents, each of which is independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, hydroxy(C1-C6)alkyl, mercapto, mercapto(C1-C6)alkyl, (C1-C6)alkylthio, halo, trifluoromethyl, trifluoromethoxy, nitro, nitrile, oxo, phenyl, —COOH, —COORA, —CORA, —SO2RA, —CONH2, —CONHNH2;
• —CONHNHRA, —CONHNRARB, —SO2NH2, —CONHRA, SO2NHRA, —CONRARB, —SO2NRARB, —NH2, —NHRA, —NRARB, —OCONH2, —OCONHRA, —OCONRARB, —NHCORA, —NHCOORA, —NRBCOORA, —NHSO2ORA, —NRBSO2ORA, —NHCONH2, —NRACONH2, —NHCONHRB, —NRACONHRB, —NHCONRARB, and —NRACONRARB wherein RA and RB are independently a (C1-C6)alkyl group.

A compound of formula (IA) or (IB) or a salt, or N-oxide thereof:

• wherein
• Ar is a 2,4-dihydroxyphenyl group which is further substituted in the 5-position by chioro or bromo;
• or by optionally substituted phenyl or C1-C6 alkyl;
• or by a phenylethyl group which is optionally substituted in the phenyl ring thereof,
• R1 and R2 are independently hydrogen, methyl, ethyl, n- or iso-propyl, hydroxyethyl, or benzyl;
• ring A is a ring of formula (IIA)
• wherein X represents N, and Y represents NRA wherein RA is a radical of formula -(Alk1)s-Q, wherein Alk1 is a C1-C3 alkylene radical and Q is optionally substituted phenyl, pyridyl, furyl, thienyl, oxadiazolyl, imidazolyl or morpholinyl, wherein optionally substituted means substituted with up to four substituents, each of which is independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, hydroxy(C1-C6)alkyl, mercapto, mercapto(C1-C6)alkyl, (C1-C6)alkylthio, halo, trifluoromethyl, trifluoromethoxy, nitro, nitrile, oxo, phenyl, —COOH, —COORA, —CORA, —SO2RA, —CONH2, —CONHNH2;
• —CONHNHRA, —CONHNRARB, —SO2NH2, —CONHRA, SO2NHRA, —CONRARB, —SO2NRARB, —NH2, —NHRA, —NRARB, —OCONH2, —OCONHRA, —OCONRARB, —NHCORA, —NHCOORA, —NRBCOORA, —NHSO2ORA, —NRBSO2ORA, —NHCONH2, —NRACONH2, —NHCONHRB, —NRACONHRB, —NHCONRARB, and —NRACONRARB wherein RA and RB are independently a (C1-C6)alkyl group.